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TACROLIMUS (ta KROE li mus) is used to decrease the immune system's response to a transplanted organ.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
They need to know if you have any of these conditions:
heart disease or heart failure
high blood pressure
immune system problems
an unusual or allergic reaction to tacrolimus, lactose, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Take this medicine by mouth with a full glass of water. If you take the medicine with food, always take it with food. Do not take the medicine with grapefruit juice. Follow the directions on the prescription label. Take your medicine at regular intervals. You must take the medicine at the same time each day. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
If you miss a dose, take it as soon as you can, and call your doctor or health care professional. Call your doctor or health care professional if you vomit after a dose.
Do not take this medicine with any of the following medications:
certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
This medicine may also interact with the following medications:
alcohol and medicines that contain alcohol
antiviral medicines for HIV or AIDS
certain antibiotics like aminoglycosides, chloramphenicol, clarithromycin, erythromycin, rifabutin, rifampin, troleandomycin
certain calcium channel blockers like diltiazem, nicardipine, nifedipine, verapamil
certain medicines for fungal infections like amphotericin B, caspofungin, clotrimazole
certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
certain medicines for stomach problems like antacids, cimetidine, famotidine, lansoprazole, metoclopramide, omeprazole
certain supplements that contain schisandra sphenanthera extracts
other medicines that prolong the QT interval (cause an abnormal heart rhythm)
St. John's wort
steroid medicines like prednisone, cortisone, methylprednisone
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
Visit your doctor or health care professional for regular checks on your progress. You will need frequent blood checks.
If you get a cold or other infection while receiving this medicine, call your doctor or health care professional. Do not treat yourself. The medicine may decrease your body's ability to fight infections.
Talk to your doctor about your risk of cancer. You may be more at risk for certain types of cancers if you take this medicine.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
burning or tingling in the hands or feet
changes in vision
difficulty breathing, wheezing
fast or irregular heartbeat
feeling faint or lightheaded, falls
fever, chills or any other sign of infection
increased thirst or hunger
loss of appetite
pain or difficulty passing urine
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
swelling of the feet or legs, unusual or sudden weight gain
unusually weak or tired
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
TACROLIMUS (ta KROE li mus) is used to decrease the immune system's response to a transplanted kidney.
Take this medicine by mouth with a full glass of water.Take this medicine in the morning on an empty stomach, at least 1 hour before or 2 hours after food. Do not take with food. Do not cut, crush or chew this medicine. Do not take the medicine with alcohol or grapefruit juice. Follow the directions on the prescription label. Take your medicine at regular intervals. You must take the medicine at the same time each day. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 16 years for selected conditions, precautions do apply.
Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.
If you miss a dose, take it as soon as you can. If your next dose is to be taken in less than 10 hours, then do not take
the missed dose. Take the next dose at your regular time. Do not take double or extra doses.
Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
TACROLIMUS (ta KROE li mus) is used to prevent organ rejection after a transplant.
an unusual or allergic reaction to tacrolimus, castor oil, other medicines, foods, dyes, or preservatives
This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.
This does not apply.
steroid medicines like prednisone or cortisone
Your condition will be monitored carefully while you are receiving this medicine.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
Your blood sugar may increase while you are taking this medicine. Call your doctor or health care professional for advice if you have any of the following symptoms: increased thirst, dry mouth, pass urine frequently, notice a fruity odor on your breath, or feel tired and lose your appetite.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
redness, blistering, peeling or loosening of the skin, including inside the mouth
trouble passing urine or change in the amount of urine
unusual bleeding or bruising
yellowing of skin or eyes
This drug is given in a hospital or clinic and will not be stored at home.
TACROLIMUS (ta KROE li mus) is used on the skin to treat eczema.
cold sores or shingles
decreased immune function
receiving any form of light therapy (phototherapy, UVA, or UVB) to your skin
an unusual or allergic reaction to tacrolimus, other medicines, foods, dyes, or preservatives
This medicine is for external use only. Follow the directions on the prescription label. Wash your hands before and after use. If treating a hand infection, wash hands before use only. Before applying this medicine, be sure your skin is completely dry. Apply a thin layer to the affected areas. Rub in gently and completely. Do not bathe, shower, or swim right after applying this medicine. This could wash off the ointment. Do not cover with a bandage or dressing unless your doctor or health care professional tells you to. You can wear normal clothing. Do not get this medicine in your eyes. If you do, rinse out with plenty of cool tap water. Do not use your medicine more often than directed.
A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
alcoholic beverages or medicines containing high percentages of alcohol
calcium channel blockers like diltiazem, nifedipine, nimodipine, nisoldipine
certain medicines used to treat fungal infections like itraconazole, ketoconazole, and fluconazole
Improvements to your skin may occur after the first few weeks of treatment. Even though your skin looks better, it is important to keep using the ointment as instructed by your health care provider. Tell your health care professional if your condition does not get better within the first few weeks of treatment or if it gets worse.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.While you are using this medicine, drinking alcohol may cause the skin or face to become flushed or red and feel hot. Let your health care provider know if you notice such reactions, especially if they bother you.
skin bleeding or change in your skin's appearance (color, change in a mole or freckle, new growth)
skin infection or infection of hair follicles
increased sensitivity of the skin to hot or cold temperatures
irritation at the site or sites where you apply this medicine including stinging, soreness, a burning feeling, tingling, or itching
Keep out of reach of children.